Research Progress In Antisense Elements (genetics)

Research Progress In Antisense Elements (genetics)

Synopsis

This book presents important research from around the world in the field of anti sense molecules which interact with complementary strands of nucleic acids, modifying expression of genes. Some regions within a double strand of DNA code for genes, which are usually instructions specifying the order of amino acids in a protein along with regulatory sequences, splicing sites, non-coding introns and other complicating details. For a cell to use this information, one strand of the DNA serves as a template for the synthesis of a complementary strand of RNA. The template DNA strand is called the transcribed strand with anti sense sequence and the mRNA transcript is said to be sense sequence (the complement of anti sense). Because the DNA is double-stranded, the strand complementary to the anti sense sequence is called non-transcribed strand and has the same sense sequence as the mRNA transcript (though T bases in DNA are substituted with U bases in RNA). Many forms of anti sense have been developed and can be broadly categorized into enzyme-dependent anti sense or steric blocking anti sense.

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